N-Desmethylenzalutamide

N-Desmethylenzalutamide is a metabolite of the antiandrogen drug enzalutamide. It is formed in the body by the cytochrome P450 enzyme CYP2C8. N-Desmethylenzalutamide has been found to possess similar antiandrogenic activity to that of enzalutamide.

Pharmacology

Pharmacodynamics

N-Desmethylenzalutamide acts as a nuclear receptor antagonist of the androgen receptor, similarly to enzalutamide. It has been found to possess similar potency and efficacy in comparison to enzalutamide in terms of androgen receptor antagonism.

Pharmacokinetics

N-Desmethylenzalutamide is formed from enzalutamide by CYP2C8 in the liver. It is a major metabolite of enzalutamide, and has similar antiandrogenic activity to that of its parent compound.

See also

• Enzalutamide
• Cytochrome P450
• Androgen receptor

References

N-Desmethylenzalutamide Resources
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