N-Nitrosodimethylamine

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A chemical compound and its implications in health and environment


N-Nitrosodimethylamine[edit | edit source]

Chemical structure of N-Nitrosodimethylamine

N-Nitrosodimethylamine (NDMA) is a semi-volatile organic chemical that belongs to a class of compounds known as nitrosamines. It is a yellow, oily liquid with a faint characteristic odor and is soluble in water, alcohol, and other organic solvents.

Chemical Properties[edit | edit source]

NDMA is a potent carcinogen and is known for its ability to form in both industrial and natural processes. It has the chemical formula C_H_N_O and a molecular weight of 74.08 g/mol. NDMA is sensitive to light and can degrade in the presence of ultraviolet light.

Sources and Formation[edit | edit source]

NDMA can be formed in the environment through the reaction of dimethylamine with nitrite under acidic conditions. It is also a byproduct of various industrial processes, including the manufacture of pesticides, rubber, and cosmetics. Additionally, NDMA can be found in trace amounts in tobacco smoke, beer, and cured meats.

Health Implications[edit | edit source]

Exposure to NDMA is a concern due to its classification as a probable human carcinogen by the International Agency for Research on Cancer (IARC). It has been linked to liver cancer and other forms of cancer in animal studies. Human exposure can occur through contaminated drinking water, food, and air.

Environmental Impact[edit | edit source]

NDMA is persistent in the environment and can contaminate groundwater and surface water. It is resistant to conventional water treatment processes, making it a challenge for water quality management. Advanced treatment methods, such as activated carbon filtration and advanced oxidation processes, are required to effectively remove NDMA from water sources.

Regulation and Safety[edit | edit source]

Due to its toxic nature, NDMA is regulated by various environmental and health agencies. The United States Environmental Protection Agency (EPA) has set a guideline for NDMA in drinking water, and it is monitored as part of the Unregulated Contaminant Monitoring Rule.

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Contributors: Prab R. Tumpati, MD