N-Phenylacetyl-L-prolylglycine ethyl ester

N-Phenylacetyl-L-prolylglycine ethyl ester (Noopept) is a nootropic agent that was patented in Russia and the United States. It is a prodrug of cycloprolylglycine, and shares similar mechanisms of action, but is much more potent by weight.

Chemistry

N-Phenylacetyl-L-prolylglycine ethyl ester is a synthetic molecule consisting of a phenylacetyl group bound to the amino terminal of a prolylglycine peptide. This structure is thought to be responsible for its nootropic effects.

Pharmacology

Noopept has been found to have various effects in the brain. It is thought to increase the expression of two neurotrophins, brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), which play important roles in cognition and memory processes.

Clinical Use

Noopept is used in Russia and certain Eastern European countries as a nootropic agent. It is prescribed for its potential to improve memory and cognitive function. However, clinical studies on its efficacy are limited and further research is needed.

Side Effects

Common side effects of Noopept include headache, fatigue, nausea, and irritability. In rare cases, it can cause allergic reactions or skin rashes.

See Also

• Nootropics
• Cycloprolylglycine
• Brain-derived neurotrophic factor
• Nerve growth factor