N-Terminal domain antiandrogen

N-Terminal domain antiandrogen is a type of antiandrogen that works by inhibiting the androgen receptor's N-terminal domain. This is a unique mechanism of action compared to other antiandrogens, which typically work by blocking the receptor's ligand-binding domain.

Mechanism of Action

N-Terminal domain antiandrogens inhibit the androgen receptor by binding to its N-terminal domain. This prevents the receptor from being activated by androgens, such as testosterone and dihydrotestosterone. As a result, these drugs can reduce the effects of androgens in the body.

Uses

N-Terminal domain antiandrogens are used in the treatment of conditions that are caused or worsened by androgens. This includes prostate cancer, which is often driven by androgens.

Examples

One example of an N-Terminal domain antiandrogen is EPI-001. This drug is still in the experimental stages and has not yet been approved for use in humans.

See Also

• Androgen receptor
• Antiandrogen
• Prostate cancer

References

N-Terminal domain antiandrogen Resources
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