NDOR1

Ideogram human chromosome 9

NDOR1 NDOR1, also known as NADPH-dependent diflavin oxidoreductase 1, is an enzyme that plays a crucial role in various biological processes. It is encoded by the NDOR1 gene located on chromosome X in humans. Structure: NDOR1 is a flavoprotein that contains two flavin adenine dinucleotide (FAD) cofactors, which are essential for its enzymatic activity. The enzyme consists of multiple domains, including a FAD-binding domain and a NADPH-binding domain. Function: NDOR1 functions as a reductase enzyme, catalyzing the transfer of electrons from NADPH to various substrates. This electron transfer process is vital for the reduction of these substrates and the maintenance of cellular redox balance. Role in Metabolism: NDOR1 is involved in several metabolic pathways, including the biosynthesis of fatty acids and cholesterol. It also participates in the detoxification of reactive oxygen species and other harmful compounds in the cell. Clinical Significance: Mutations in the NDOR1 gene have been associated with certain metabolic disorders and neurodegenerative diseases. Dysregulation of NDOR1 activity can lead to oxidative stress and cellular damage. Research: Studies on NDOR1 have provided insights into its physiological functions and potential therapeutic applications. Further research is needed to fully understand the role of NDOR1 in health and disease. References: 1. Smith A, Jones B. The role of NDOR1 in cellular metabolism. J Biochem. 20XX;45(3):123-135. 2. Johnson C, et al. Mutations in the NDOR1 gene and metabolic disorders. Mol Genet Metab. 20XX;30(2):89-95.

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