NFAM1

NFAM1 (NFAT Activating Protein with ITAM Motif 1) is a protein that in humans is encoded by the NFAM1 gene. This protein is a member of the immunoglobulin superfamily and is identified as a receptor expressed on the surface of lymphocytes.

Function

NFAM1 is an immunoreceptor that is expressed in B cells and natural killer cells. It plays a crucial role in the activation of these cells and is involved in the regulation of immune responses. NFAM1 activates calcium signaling pathways that lead to the activation of the transcription factor NFAT (nuclear factor of activated T-cells). This activation is important for the production of cytokines and the proliferation of immune cells.

Clinical Significance

Alterations in the NFAM1 gene have been associated with various autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. Further research is needed to fully understand the role of NFAM1 in these diseases and its potential as a therapeutic target.

Structure

The NFAM1 protein is a type I transmembrane protein with an extracellular region that contains an immunoglobulin-like domain. The cytoplasmic region of the protein contains an ITAM (Immunoreceptor Tyrosine-based Activation Motif), which is crucial for the activation of downstream signaling pathways.

External links

• GeneReviews/NCBI/NIH/UW entry on NFAM1
• UniProt entry on NFAM1