NK012
NK012 is a nanoparticle drug delivery system that is used to deliver SN-38, the active metabolite of Irinotecan. It was developed by Nippon Kayaku.
Mechanism of action[edit | edit source]
NK012 is a polymer-drug conjugate that uses a polyglutamic acid (PGA) polymer to deliver SN-38. The PGA polymer is linked to SN-38 via a ester bond, which is cleaved in the body to release the active drug. The nanoparticle formulation allows for a higher concentration of the drug to be delivered to tumor cells, while reducing the exposure of healthy cells to the drug.
Clinical trials[edit | edit source]
NK012 has been tested in clinical trials for various types of cancer, including colorectal cancer, non-small cell lung cancer, and ovarian cancer. In a phase I clinical trial, NK012 showed promising results in patients with advanced solid tumors. However, in a phase II clinical trial for non-small cell lung cancer, the drug did not meet its primary endpoint of improving progression-free survival.
Side effects[edit | edit source]
The most common side effects of NK012 are neutropenia, diarrhea, and fatigue. Severe neutropenia was reported in a significant number of patients in clinical trials.
See also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
