NRG2

NRG2 (Neuregulin 2) is a protein that in humans is encoded by the NRG2 gene. It is a member of the neuregulin protein family which in turn is a part of the EGF family of proteins. NRG2 has been found to activate the ErbB family of receptors, which are critical for the development and function of the nervous system.

Function

NRG2 is a ligand for the ErbB4 receptor. It can activate the AKT and ERK pathways, and it can induce the expression of acetylcholine receptor in vitro. NRG2 is also known to promote the survival of neurons and to be involved in the maturation of Schwann cells.

Clinical significance

Alterations in the NRG2 gene have been associated with schizophrenia. Studies have shown that NRG2 may play a role in the pathogenesis of this disorder. In addition, NRG2 has been implicated in the development of certain types of cancer, including breast cancer and lung cancer.

See also

• Neuregulin
• ErbB
• EGF
• Schizophrenia
• Cancer

External links

• GeneCards - NRG2