Nebivolol/valsartan

Nebivolol/valsartan is a combination medication used in the treatment of hypertension (high blood pressure). It contains two active ingredients: nebivolol, a beta blocker, and valsartan, an angiotensin II receptor antagonist.

Pharmacology

Nebivolol is a selective beta1 receptor blocker. It works by reducing the heart rate, the heart's workload and the heart's output, which helps to decrease blood pressure. Nebivolol also has vasodilatory properties, which means it can help to widen the blood vessels, further reducing blood pressure.

Valsartan is an angiotensin II receptor antagonist. It works by blocking the action of angiotensin II, a chemical in the body that causes blood vessels to tighten. By blocking the action of angiotensin II, valsartan allows blood vessels to relax and widen, which can lower blood pressure.

Clinical Use

Nebivolol/valsartan is used to treat hypertension. It is typically prescribed when one medication alone is not sufficient to control blood pressure. The combination of nebivolol and valsartan can provide better blood pressure control than either medication alone.

Side Effects

Common side effects of nebivolol/valsartan include headache, dizziness, fatigue, and nausea. In rare cases, it can cause serious side effects such as hypotension (low blood pressure), bradycardia (slow heart rate), and hyperkalemia (high potassium levels in the blood).

Contraindications

Nebivolol/valsartan should not be used in patients with severe liver disease, kidney disease, or in patients who are pregnant or breastfeeding. It should also not be used in patients who have a known hypersensitivity to either nebivolol or valsartan.

See Also

• Beta blocker
• Angiotensin II receptor antagonist
• Hypertension