Neurofibroma

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Neurofibroma
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Skin lesions, pain, neurological deficits
Complications	Malignant transformation, nerve compression
Onset	Usually in adolescence or early adulthood
Duration	Chronic
Types	N/A
Causes	Genetic mutation in the NF1 gene
Risks	Family history of neurofibromatosis type I
Diagnosis	Clinical examination, imaging studies, biopsy
Differential diagnosis	Schwannoma, dermatofibroma, lipoma
Prevention	N/A
Treatment	Surgical excision, radiotherapy, chemotherapy
Medication	Pain management, anti-inflammatory drugs
Prognosis	Generally benign, but risk of malignant transformation
Frequency	Common in individuals with neurofibromatosis type I
Deaths	N/A

Dermal Neurofibroma

Neurofibroma illustration from Gould and Pyle

Neurofibroma

Neurofibroma

Histopathology of Neurofibroma

Neurofibroma, Right Upper Back

Neurofibroma is a type of tumor that originates from the nervous system. It is often associated with Neurofibromatosis type I, a genetic disorder that affects the cell growth in the nervous system. Neurofibromas are typically benign, but they can become malignant in some cases.

Types

There are three main types of neurofibromas: cutaneous, subcutaneous, and plexiform.

• Cutaneous neurofibromas are the most common type. They appear as small, soft bumps on or under the skin. They are usually harmless and do not require treatment unless they cause discomfort or cosmetic concerns.
• Subcutaneous neurofibromas are deeper than cutaneous neurofibromas. They can cause pain and discomfort, especially if they press on nerves or other structures.
• Plexiform neurofibromas are the most serious type. They can grow large and cause significant pain and other symptoms. They also have a higher risk of becoming malignant.

Symptoms

The symptoms of neurofibroma can vary depending on the type and location of the tumor. Common symptoms include:

• Skin bumps
• Pain or discomfort
• Changes in skin color
• Weakness or numbness in the affected area

Diagnosis

Neurofibromas are usually diagnosed through a combination of physical examination, medical history, and imaging tests such as MRI or CT scan. In some cases, a biopsy may be needed to confirm the diagnosis.

Treatment

The treatment for neurofibroma depends on the type, size, and location of the tumor, as well as the patient's overall health. Options may include:

• Observation: If the neurofibroma is small and not causing any symptoms, it may be monitored without active treatment.
• Surgery: If the neurofibroma is causing symptoms or has a high risk of becoming malignant, it may be removed surgically.
• Radiation therapy: This may be used if the neurofibroma cannot be completely removed surgically, or if it has become malignant.
• Medication: Certain medications can help manage the symptoms of neurofibroma.

See also

• Neurofibromatosis
• Tumor
• Nervous system

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