Neuromedin B

Neuromedin B (NMB) is a neuropeptide that is part of the bombesin-like peptide family. It is encoded by the NMB gene in humans and is widely distributed in the central nervous system and peripheral tissues.

Function

Neuromedin B functions as a neurotransmitter or neuromodulator. It is involved in various physiological processes, including the regulation of body temperature, blood pressure, pain perception, and feeding behavior. It also plays a role in the growth of certain types of cancer cells.

Structure

The NMB gene encodes a preproprotein that is processed to generate the mature peptide. This peptide is a 10-amino acid long molecule that shares a common C-terminal sequence with other members of the bombesin-like peptide family.

Receptor

Neuromedin B exerts its effects by binding to the Neuromedin B receptor (NMBR), a G-protein coupled receptor. This receptor is expressed in various tissues, including the brain, lung, and gastrointestinal tract.

Clinical significance

Alterations in the expression or function of Neuromedin B or its receptor have been implicated in several diseases, including obesity, hypertension, and various types of cancer.

See also

• Neuropeptide
• Bombesin
• Neuromedin B receptor
• Neurotransmitter
• Neuromodulator

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