Neuropeptide S

Neuropeptide S (NPS) is a neuropeptide that is involved in the regulation of sleep and anxiety. It is produced in the brain and acts on the Neuropeptide S receptor (NPSR), a G protein-coupled receptor.

Function[edit | edit source]

Neuropeptide S is known to promote wakefulness and anxiolytic-like effects. It is released in response to stress and can increase arousal and alertness. The peptide also has a role in modulating the hypothalamic-pituitary-adrenal axis, which is involved in the body's response to stress.

Structure[edit | edit source]

The structure of Neuropeptide S is unique among neuropeptides. It is a 20-amino acid peptide with a sequence that is highly conserved across species. The NPSR is a G protein-coupled receptor that is activated by NPS.

Role in Disease[edit | edit source]

Alterations in the NPS system have been implicated in several psychiatric disorders, including anxiety disorders, panic disorder, and post-traumatic stress disorder (PTSD). In addition, variations in the NPSR gene have been associated with panic disorder.

Therapeutic Potential[edit | edit source]

Due to its role in anxiety and sleep regulation, the NPS system is a potential target for the development of new treatments for anxiety disorders and sleep disorders. However, more research is needed to fully understand the role of NPS in these conditions and to develop effective therapies.