Neurotrophin-4

Neurotrophin-4 (NT-4) is a protein that in humans is encoded by the NTF4 gene. It is one of the neurotrophins, a family of proteins that induce the survival, development, and function of neurons.

Function

NT-4 is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. It is known to promote the survival and differentiation of mammalian neurons, and may play a role in the injury response in the nervous system.

Clinical significance

Mutations in this gene have been associated with glaucoma 1O (GLC1O), a form of primary open angle glaucoma.

See also

• Neurotrophin
• TrkB
• Glaucoma

External links

• GeneReviews/NCBI/NIH/UW entry on Primary Open-Angle Glaucoma

Neurotrophin-4 Resources
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