TrkB

TrkB

The TrkB receptor, also known as Tropomyosin receptor kinase B, is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5.

Function

TrkB is part of the large family of receptor tyrosine kinases. It has a high affinity for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). TrkB activation by BDNF and NT-4 leads to phosphorylation of the receptor, which triggers a series of intracellular signaling cascades.

Clinical significance

Alterations in the function of the TrkB receptor and its ligands have been linked to several neurodegenerative diseases, depression, and cancer. TrkB has been considered as a potential therapeutic target in these conditions.

See also

• Tropomyosin receptor kinase A
• Tropomyosin receptor kinase C
• Neurotrophin

External links

• NTRK2 gene on NCBI

TrkB Resources
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