TrkB
TrkB
The TrkB receptor, also known as Tropomyosin receptor kinase B, is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5.
Function[edit | edit source]
TrkB is part of the large family of receptor tyrosine kinases. It has a high affinity for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). TrkB activation by BDNF and NT-4 leads to phosphorylation of the receptor, which triggers a series of intracellular signaling cascades.
Clinical significance[edit | edit source]
Alterations in the function of the TrkB receptor and its ligands have been linked to several neurodegenerative diseases, depression, and cancer. TrkB has been considered as a potential therapeutic target in these conditions.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- NTRK2 gene on NCBI
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Contributors: Prab R. Tumpati, MD
