Neutrophilic lobular panniculitis

Neutrophilic lobular panniculitis is a rare type of panniculitis, a group of conditions characterized by inflammation of the subcutaneous fat. It is characterized by the presence of neutrophils in the lobules of the subcutaneous fat, hence the name.

Etiology

The exact cause of neutrophilic lobular panniculitis is unknown. However, it has been associated with various conditions such as autoimmune diseases, infections, and malignancies. Some cases have also been reported following the use of certain medications.

Clinical Presentation

Patients with neutrophilic lobular panniculitis typically present with tender, erythematous nodules or plaques on the skin. These lesions are most commonly found on the legs, but can occur anywhere on the body. Other symptoms may include fever, malaise, and weight loss.

Diagnosis

Diagnosis of neutrophilic lobular panniculitis is made based on clinical presentation and histopathological examination of a skin biopsy. The characteristic finding on histopathology is lobular inflammation of the subcutaneous fat with a predominance of neutrophils.

Treatment

Treatment of neutrophilic lobular panniculitis is aimed at reducing inflammation and managing any underlying conditions. This may involve the use of anti-inflammatory medications, immunosuppressive drugs, or antibiotics, depending on the individual patient's circumstances.

Prognosis

The prognosis of neutrophilic lobular panniculitis varies depending on the severity of the condition and any associated diseases. In some cases, the condition may resolve spontaneously, while in others, it may persist or recur.

See Also

• Panniculitis
• Neutrophils
• Subcutaneous fat