Livedoid dermatitis
(Redirected from Nicolau syndrome)
Livedoid Dermatitis is a rare skin condition characterized by painful, ulcerative lesions that predominantly affect the lower extremities. The condition is also known as Livedoid Vasculopathy and Atrophie Blanche.
Etiology[edit | edit source]
The exact cause of Livedoid Dermatitis is unknown. However, it is believed to be associated with certain conditions such as thrombophilia, hypercoagulable states, and autoimmune diseases.
Clinical Presentation[edit | edit source]
Patients with Livedoid Dermatitis typically present with painful, ulcerative lesions on the lower extremities. These lesions are often surrounded by a livedoid, or net-like, pattern of erythema. Over time, the lesions may heal with atrophic, porcelain-white scars known as Atrophie Blanche.
Diagnosis[edit | edit source]
Diagnosis of Livedoid Dermatitis is primarily based on clinical presentation and histopathological examination of skin biopsies. The histopathology typically shows fibrinoid necrosis of the dermal vessels and a perivascular lymphocytic infiltrate.
Treatment[edit | edit source]
Treatment of Livedoid Dermatitis is challenging and often requires a multidisciplinary approach. Options include anticoagulants, antiplatelet agents, immunosuppressants, and pain management strategies.
Prognosis[edit | edit source]
The prognosis of Livedoid Dermatitis is variable. While the condition is not life-threatening, it can significantly impact the quality of life due to chronic pain and recurrent ulcerations.
See Also[edit | edit source]
References[edit | edit source]
- Livedoid Vasculopathy: A Review of Pathogenesis and Principles of Management
- Livedoid Dermatitis: A Case Report and Review of the Literature
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Contributors: Prab R. Tumpati, MD