Nisoxetine

Nisoxetine.svg

Selective norepinephrine reuptake inhibitor

Nisoxetine
Chemical nomenclature
IUPAC name	(RS)-3-(2-Methoxyphenoxy)-3-phenylpropan-1-amine
Identifiers
CAS Number	62391-90-8
PubChem	4495
ChemSpider	4338
UNII	0J9L7J6V8I
KEGG	D05100
ChEMBL	2104010
Chemical data
Chemical formula	C16H19N1O2
SMILES	COc1ccccc1OCC(Cc2ccccc2)N
InChI	1S/C16H19NO2/c1-18-15-10-6-5-9-14(15)19-12-16(17)11-13-7-3-2-4-8-13/h2-10,16H,11-12,17H2,1H3
InChIKey	YRCWQPVGYLYSOX-UHFFFAOYSA-N

Nisoxetine is a selective norepinephrine reuptake inhibitor (NRI) that was initially developed as an antidepressant but was never marketed. It is primarily used in scientific research to study the role of norepinephrine in the central nervous system.

Pharmacology

Nisoxetine functions by inhibiting the reuptake of norepinephrine (NE) into presynaptic neurons, thereby increasing the concentration of NE in the synaptic cleft and enhancing its activity at postsynaptic receptors. This mechanism is similar to that of other NRIs such as atomoxetine and reboxetine.

Chemical Structure

The chemical structure of nisoxetine is characterized by a phenoxy group attached to a propanamine chain, with a methoxy group at the ortho position of the phenoxy ring. Its IUPAC name is (RS)-3-(2-Methoxyphenoxy)-3-phenylpropan-1-amine.

Research Applications

Nisoxetine is widely used in neuroscience research to investigate the effects of increased norepinephrine levels on various physiological and behavioral processes. Studies have utilized nisoxetine to explore its impact on mood disorders, attention-deficit hyperactivity disorder (ADHD), and pain management.

See Also

• Norepinephrine reuptake inhibitor
• Antidepressant
• Atomoxetine
• Reboxetine