Non-cirrhotic portal fibrosis

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Non-cirrhotic portal fibrosis
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Non-cirrhotic portal fibrosis (NCPF) is a chronic liver disease[1] and type of non-cirrhotic portal hypertension (NCPH).

Presentation[edit | edit source]

It is characterized by 'obliterative portovenopathy', which leads to various problems such as portal hypertension, massive splenomegaly, and variceal bleeding. It is estimated that about 85% of people with NCPF have repeated episodes of variceal bleeding.[2]

Diagnosis[edit | edit source]

Hallmark of the disease is thrombosis/sclerosis of branches of portal vein. Vessels formed are often termed as mesangiosinusoids or periportal cavernoma.

Treatment[edit | edit source]


References[edit | edit source]

  1. , Non-cirrhotic portal fibrosis: one disease with many names? An analysis from morphological study of native explant livers with end stage chronic liver disease., Journal of Clinical Pathology, Vol. 64(Issue: 7), pp. 592–8, DOI: 10.1136/jcp.2010.087395, PMID: 21685145,
  2. , Non-cirrhotic portal fibrosis., Journal of Gastroenterology and Hepatology, Vol. 17 Suppl 3 pp. S214-23, PMID: 12472939,

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Non-cirrhotic portal fibrosis Resources
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