Norpholedrine

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Norpholedrine‏‎ (also known as Phenylpropanolamine or PPA) is a psychoactive drug of the phenethylamine and amphetamine chemical classes that is used as a stimulant, decongestant, and anorectic agent. It is commonly used in prescription and over-the-counter cough and cold preparations. In veterinary medicine, it is used to control urinary incontinence in dogs.

Chemistry[edit | edit source]

Norpholedrine‏‎ is a phenethylamine and amphetamine derivative. It is structurally similar to ephedrine, and works primarily as a norepinephrine releasing agent.

Medical uses[edit | edit source]

Norpholedrine‏‎ is used as a decongestant and anorectic agent. It is also used in the treatment of urinary incontinence in dogs.

Side effects[edit | edit source]

Common side effects of Norpholedrine‏‎ include nervousness, restlessness, and insomnia. More serious side effects may include high blood pressure, stroke, and serious heart problems.

Regulation[edit | edit source]

In many countries, including the United States, Norpholedrine‏‎ has been withdrawn from the market due to its potential for misuse and its serious side effects.

See also[edit | edit source]


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Contributors: Prab R. Tumpati, MD