Nortetrazepam

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Nortetrazepam is a benzodiazepine derivative. It is a minor active metabolite of diazepam, temazepam, and oxazepam. Nortetrazepam is known for its anxiolytic, anticonvulsant, sedative, and muscle relaxant properties.

Pharmacology

Nortetrazepam works by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, which results in its calming effects on the central nervous system (CNS). This mechanism is similar to other benzodiazepines.

Metabolism

Nortetrazepam is formed as a metabolite during the breakdown of diazepam, temazepam, and oxazepam in the body. The metabolic pathway involves the hepatic enzyme system, particularly the cytochrome P450 enzymes.

Medical Uses

Nortetrazepam is used in the treatment of various conditions, including:

• Anxiety disorders
• Insomnia
• Seizure disorders
• Muscle spasms

Side Effects

Common side effects of Nortetrazepam include:

• Drowsiness
• Dizziness
• Fatigue
• Ataxia

Legal Status

The legal status of Nortetrazepam varies by country. In many places, it is classified as a controlled substance due to its potential for abuse and dependence.

See Also

• Benzodiazepine
• Diazepam
• Temazepam
• Oxazepam

References

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