NPM1

NPM1 or Nucleophosmin is a protein that in humans is encoded by the NPM1 gene. It is involved in several processes such as ribosome biogenesis, centrosome duplication, and cell cycle progression. Mutations in this gene are associated with acute myeloid leukemia (AML).

Function

Nucleophosmin (NPM1) is a nucleolar phosphoprotein that plays a role in ribosome biogenesis and is involved in the regulation of cell proliferation. It is also associated with the centrosome during mitosis and is a critical component of the cell cycle progression machinery.

Clinical significance

Mutations in the NPM1 gene are associated with acute myeloid leukemia (AML). These mutations often result in the cytoplasmic dislocation of the NPM1 protein, which is a characteristic feature of a subtype of AML. The NPM1 mutation is one of the most common genetic alterations in AML, occurring in about 30% of cases.

See also

• Acute myeloid leukemia
• Nucleophosmin
• Cell cycle
• Centrosome
• Ribosome biogenesis

External links

• NPM1 at the National Center for Biotechnology Information