O-1918
O-1918[edit | edit source]
O-1918 is a synthetic compound that acts as a selective antagonist of the cannabinoid receptor GPR55. It is structurally related to the cannabinoid CP-55940, but it has been modified to remove its activity at the classical cannabinoid receptors CB1 and CB2.
Chemical Structure[edit | edit source]
O-1918 is a derivative of the cannabinoid CP-55940, with specific modifications that confer its selectivity for GPR55. The chemical structure of O-1918 is characterized by the presence of a phenolic hydroxyl group and a carboxylic acid moiety, which are crucial for its activity as a GPR55 antagonist.
Mechanism of Action[edit | edit source]
O-1918 functions primarily as an antagonist of the GPR55 receptor, a G protein-coupled receptor that has been implicated in various physiological processes, including pain, inflammation, and cancer. By blocking GPR55, O-1918 can modulate these processes, making it a compound of interest in pharmacology and therapeutics.
Pharmacological Effects[edit | edit source]
The pharmacological effects of O-1918 are primarily related to its action on GPR55. Studies have shown that O-1918 can inhibit GPR55-mediated calcium signaling, which is involved in various cellular responses. This inhibition can lead to reduced cell proliferation and migration, particularly in cancer cells, suggesting potential applications in oncology.
Research Applications[edit | edit source]
O-1918 is used extensively in research to study the role of GPR55 in various biological systems. It serves as a valuable tool for dissecting the signaling pathways mediated by GPR55 and for exploring the therapeutic potential of targeting this receptor in diseases such as cancer, neuropathic pain, and inflammatory disorders.
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