Obidoxime

Obidoxime is a chemical compound used as an antidote in the treatment of organophosphate poisoning. It belongs to a class of drugs known as oximes, which are used to reactivate acetylcholinesterase, an enzyme that is inhibited by organophosphates.

Chemistry

Obidoxime is a dichloride salt and is chemically known as 1,1'-obis(pyridin-2-aldoximato)-N,N'-dimethylmethanediiminium dichloride. It is a white to off-white crystalline powder that is soluble in water and has a molecular weight of 359.2 g/mol.

Mechanism of Action

Obidoxime works by reactivating acetylcholinesterase, an enzyme that is essential for normal nerve function. Organophosphates inhibit this enzyme, leading to an accumulation of acetylcholine in the body, which can cause a range of symptoms including muscle weakness, breathing difficulties, and potentially death. Obidoxime binds to the organophosphate, removing it from the enzyme and allowing it to function normally again.

Uses

Obidoxime is used in the treatment of poisoning by organophosphates, which are commonly found in pesticides and nerve gases. It is often used in combination with atropine, another antidote that helps to counteract the effects of excess acetylcholine.

Side Effects

Like all medications, obidoxime can cause side effects. These may include nausea, vomiting, and allergic reactions. In rare cases, it can cause more serious side effects such as heart problems or seizures.

See Also

• Pralidoxime
• Organophosphate poisoning
• Acetylcholinesterase