Octreotate

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Octreotate

Octreotate is a synthetic analog of the natural hormone somatostatin. It is primarily used in the treatment of certain types of neuroendocrine tumors due to its ability to inhibit the release of various hormones and other secretions.

Chemical Structure and Properties

Octreotate is a modified form of octreotide, which itself is a synthetic version of somatostatin. The modification involves the addition of a DOTA chelator, which allows for the binding of radioactive isotopes. This property makes octreotate particularly useful in radiopharmaceuticals for both diagnostic and therapeutic purposes.

Mechanism of Action

Octreotate works by binding to somatostatin receptors (SSTRs), which are overexpressed in many neuroendocrine tumors. By binding to these receptors, octreotate inhibits the release of growth hormone, insulin, and other peptides, thereby slowing the growth of the tumor and alleviating symptoms.

Clinical Uses

Octreotate is used in the treatment of various neuroendocrine tumors, including:

• Carcinoid tumors
• Gastroenteropancreatic neuroendocrine tumors (GEP-NETs)
• Pituitary adenomas

It is often used in conjunction with radiolabeled isotopes such as Lutetium-177 (Lu-177) for Peptide Receptor Radionuclide Therapy (PRRT).

Side Effects

Common side effects of octreotate include:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Hyperglycemia

Related Compounds

• Octreotide
• Lanreotide
• Pasireotide

See Also

• Somatostatin
• Neuroendocrine tumors
• Peptide Receptor Radionuclide Therapy
• Radiopharmaceuticals