Ofuji disease
Ofuji Disease[edit | edit source]
Ofuji disease, also known as eosinophilic pustular folliculitis, is a rare dermatological condition characterized by recurrent crops of sterile pustules primarily affecting the face, scalp, and trunk. It is named after the Japanese dermatologist Shigeo Ofuji, who first described the condition in 1970.
Clinical Presentation[edit | edit source]
Patients with Ofuji disease typically present with pruritic, erythematous papules and pustules. These lesions are often arranged in annular or serpiginous patterns. The condition predominantly affects young adults, with a higher incidence in males.
Pathophysiology[edit | edit source]
The exact pathogenesis of Ofuji disease remains unclear. However, it is believed to involve an abnormal immune response, particularly involving eosinophils. Eosinophils are a type of white blood cell that play a role in allergic reactions and asthma. In Ofuji disease, there is an infiltration of eosinophils around the hair follicles, leading to the formation of pustules.
Diagnosis[edit | edit source]
Diagnosis of Ofuji disease is primarily clinical, supported by histopathological examination. A skin biopsy typically shows eosinophilic infiltration around the hair follicles. Differential diagnosis includes other forms of folliculitis, such as bacterial folliculitis and acne vulgaris.
Treatment[edit | edit source]
Treatment options for Ofuji disease include topical and systemic therapies. Topical corticosteroids and tacrolimus are commonly used to reduce inflammation. Systemic treatments may include oral corticosteroids, dapsone, and indomethacin. In some cases, phototherapy has been found to be effective.
Prognosis[edit | edit source]
The prognosis for Ofuji disease is generally good, although it can be a chronic condition with recurrent episodes. Long-term management may be necessary to control symptoms and prevent flare-ups.
Epidemiology[edit | edit source]
Ofuji disease is rare, with most cases reported in Japan. However, it has been documented in other populations worldwide. The condition is more common in males than females.
See Also[edit | edit source]
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NIH genetic and rare disease info[edit source]
Ofuji disease is a rare disease.
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