Ondelopran

Ondelopran

Ondelopran chemical structure

Ondelopran is a pharmaceutical drug that belongs to the class of serotonin receptor antagonists. It is primarily used in the management of nausea and vomiting induced by chemotherapy, radiotherapy, and surgery. Ondelopran works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting.

Mechanism of Action

Ondelopran functions as a selective antagonist of the 5-HT3 receptor, a subtype of serotonin receptor found in the central nervous system and the gastrointestinal tract. By inhibiting these receptors, Ondelopran prevents the activation of the vomiting center in the brain, thereby reducing the sensation of nausea and the reflex to vomit.

Clinical Uses

Ondelopran is widely used in the prevention and treatment of:

• Chemotherapy-induced nausea and vomiting (CINV)
• Postoperative nausea and vomiting (PONV)
• Radiotherapy-induced nausea and vomiting

It is often administered in combination with other antiemetic agents to enhance its efficacy, particularly in patients undergoing highly emetogenic chemotherapy.

Administration and Dosage

Ondelopran is available in various forms, including oral tablets, intravenous injection, and oral disintegrating tablets. The dosage and route of administration depend on the specific condition being treated, the patient's response, and other individual factors such as age and weight.

Side Effects

Common side effects of Ondelopran include:

• Headache
• Constipation
• Dizziness
• Fatigue

Serious side effects, although rare, may include allergic reactions, QT interval prolongation, and serotonin syndrome. Patients are advised to seek medical attention if they experience symptoms such as chest pain, irregular heartbeat, or severe dizziness.

Contraindications

Ondelopran is contraindicated in patients with known hypersensitivity to the drug or any of its components. Caution is advised in patients with a history of cardiac arrhythmias or electrolyte imbalances.

Pharmacokinetics

Ondelopran is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1 to 2 hours. It is extensively metabolized in the liver and excreted primarily in the urine. The elimination half-life of Ondelopran is approximately 3 to 6 hours.

Related Pages

• Serotonin receptor antagonist
• Chemotherapy-induced nausea and vomiting
• Postoperative nausea and vomiting
• Serotonin