Estradiol monopropionate

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Estradiol monopropionate (EMP), also known as estradiol 17β-monopropionate, is a steroidal estrogen that is used in hormone therapy. It is a synthetic, steroidal estrogen and a derivative of estradiol, the primary female sex hormone. EMP is used primarily in the treatment of menopausal symptoms and hormone deficiency in women, but it also has uses in the treatment of breast cancer and prostate cancer.

Pharmacology[edit | edit source]

EMP is a prodrug of estradiol, meaning it is metabolized in the body into estradiol. It is administered via intramuscular injection, and has a longer duration of action than estradiol itself due to its prodrug nature. The propionate ester in EMP serves to increase its lipophilicity, which allows it to be stored in fatty tissues for extended periods of time.

Medical uses[edit | edit source]

EMP is used primarily in hormone therapy for menopausal symptoms and hormone deficiency in women. It can help to alleviate symptoms such as hot flashes, vaginal dryness, and mood swings. In addition, EMP is used in the treatment of certain types of breast cancer in women and prostate cancer in men.

Side effects[edit | edit source]

Like all estrogens, EMP has potential side effects. These can include nausea, breast tenderness, fluid retention, and an increased risk of certain conditions such as blood clots, stroke, and certain types of cancer.

See also[edit | edit source]


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