Oxoeicosanoid receptor 1

Oxoeicosanoid receptor 1 (OXER1), also known as OXE receptor or OXE-R, is a protein that in humans is encoded by the OXER1 gene. OXER1 is a member of the G protein-coupled receptor (GPCR) family, which are integral membrane proteins that possess seven transmembrane domains.

Function

OXER1 is a receptor for oxoeicosanoids, a class of signaling molecules derived from arachidonic acid. The receptor is coupled to a Gq/11 protein, which activates phospholipase C and leads to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). This in turn triggers a rise in intracellular calcium levels and activates protein kinase C.

Clinical significance

OXER1 has been implicated in a variety of physiological and pathological processes. It is involved in the regulation of inflammation, pain perception, and cancer progression. In particular, it has been associated with the development and progression of prostate cancer and breast cancer.

See also

• G protein-coupled receptor
• Oxoeicosanoid
• Arachidonic acid
• Inflammation
• Pain
• Cancer
• Prostate cancer
• Breast cancer

External links

• OXER1 at HUGO Gene Nomenclature Committee
• OXER1 at UniProt

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