Oxytocin/neurophysin i prepropeptide

Oxytocin/neurophysin I prepropeptide is a protein that in humans is encoded by the OXT gene. It is a hormone that plays a significant role in the neuroanatomy of intimacy, specifically in sexual reproduction of both sexes, in particular during and after childbirth.

Structure

The structure of the oxytocin/neurophysin I prepropeptide is complex. It is a precursor molecule that is cleaved to produce oxytocin and neurophysin I. Oxytocin is a nine amino acid peptide that is synthesized as an inactive precursor protein from the OXT gene.

Function

Oxytocin is a hormone that is made in the hypothalamus, a part of the brain. It is then transported to, stored, and secreted by the pituitary gland, a small gland at the base of the brain. Oxytocin plays a crucial role in the childbirth process and also helps with male reproduction.

Clinical significance

Alterations in the OXT gene have been associated with a number of conditions, such as autism, depression, and anxiety disorders. Oxytocin and its receptor are also involved in the regulation of stress, social behavior, and sexual reproduction, suggesting that they may play a key role in the pathophysiology of these conditions.

See also

• Oxytocin receptor
• Neurophysin I
• Pituitary gland
• Hypothalamus

References

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