P-hydroxyphenylacetone

P-hydroxyphenylacetone (also known as p-Hydroxyphenyl-2-propanone or 4'-Hydroxyphenylacetone) is a chemical compound that belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system made up of benzene.

Chemical Structure

P-hydroxyphenylacetone is a phenolic compound, which means it contains a phenol group (-OH) attached to a benzene ring. The chemical formula of p-hydroxyphenylacetone is C9H10O2. It has a molar mass of 150.17 g/mol. The structure of p-hydroxyphenylacetone consists of a benzene ring substituted with a hydroxy group (OH) and an acetone group (CH3CO).

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Chemical structure of P-hydroxyphenylacetone

Properties

P-hydroxyphenylacetone is a solid at room temperature. It has a melting point of 71-74 °C and a boiling point of 295 °C. It is soluble in water and most organic solvents. P-hydroxyphenylacetone is a weak acid, with a pKa value of 10.07.

Synthesis

P-hydroxyphenylacetone can be synthesized from phenol and acetone in the presence of an acid catalyst such as sulfuric acid. The reaction proceeds via a Friedel-Crafts acylation mechanism.

Applications

P-hydroxyphenylacetone is used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is also used in the production of polymers and resins, and as a starting material in the synthesis of other organic compounds.

Safety

P-hydroxyphenylacetone is a hazardous substance. It can cause skin and eye irritation, and prolonged exposure can lead to serious health effects. Proper safety measures should be taken when handling this compound.

See Also

• Phenol
• Acetone
• Benzene
• Friedel-Crafts acylation