P14arf
P14arf is a tumor suppressor protein that in humans is encoded by the CDKN2A gene. This protein is an important regulator of the cell cycle and functions as a sensor of oncogenic signals, leading to cell cycle arrest.
Function[edit | edit source]
P14arf is a product of the CDKN2A locus, which generates two major transcripts through alternative splicing and use of different reading frames. The other product is p16INK4a, a cyclin-dependent kinase inhibitor. P14arf functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM2, a protein responsible for the degradation of p53. With MDM2 sequestered, p53 can accumulate and act as a transcription factor to induce cell cycle arrest and apoptosis in response to DNA damage and oncogenic signals.
Clinical significance[edit | edit source]
Mutations in the CDKN2A gene, and therefore in the p14arf protein, are associated with a variety of cancers, including melanoma, pancreatic cancer, and lung cancer. These mutations often result in a loss of function of the p14arf protein, leading to uncontrolled cell proliferation.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
P14arf Resources | ||
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