PDX
PDX or Patient Derived Xenograft is a type of cancer research technique where cancerous tissue from a patient is implanted into an immunodeficient mouse for study. This method is used to create a model that closely mimics the patient's disease, allowing for personalized treatment strategies.
History[edit | edit source]
The use of PDX models in cancer research began in the 1980s. The technique was developed as a way to study the biology of human cancers in an in vivo setting. Over the years, PDX models have been used to study a variety of cancers, including breast cancer, lung cancer, colorectal cancer, and pancreatic cancer.
Methodology[edit | edit source]
The process of creating a PDX model begins with the surgical removal of a tumor from a patient. The tumor tissue is then implanted into an immunodeficient mouse, either subcutaneously or orthotopically (in the same organ from which the tumor originated). The mouse is then monitored for tumor growth. Once the tumor has grown to a sufficient size, it can be removed and further implanted into additional mice for study.
Applications[edit | edit source]
PDX models are used in a variety of research applications. They are often used in drug discovery and preclinical trials to test the efficacy of new cancer treatments. PDX models can also be used to study the biology of cancer, including tumor growth, metastasis, and response to therapy.
Limitations[edit | edit source]
While PDX models are a valuable tool in cancer research, they do have some limitations. One major limitation is that they require the use of immunodeficient mice, which do not fully represent the human immune system. This can limit the ability to study the role of the immune system in cancer progression and response to therapy. Additionally, the process of creating a PDX model can be time-consuming and expensive.
See Also[edit | edit source]
| PDX Resources | |
|---|---|
 |
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
