PHTPP

PHTPP (4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol) is a selective antagonist of the estrogen receptor subtype ERβ. It is used in scientific research to understand the role of ERβ in the body and the differences between the two estrogen receptors, ERα and ERβ.

Chemistry

PHTPP is a synthetic compound that belongs to the class of organic compounds known as phenylpyrazoles. It is composed of a phenyl group attached to a pyrazole ring, which is further substituted with a trifluoromethyl group and a phenol group.

Pharmacology

PHTPP acts as a selective antagonist of ERβ, meaning it binds to this receptor and blocks its activation by estrogen. This allows researchers to study the specific effects of ERβ in the body, separate from the effects of ERα.

Uses in Research

PHTPP has been used in a variety of research studies to understand the role of ERβ in different physiological processes. For example, it has been used to study the role of ERβ in the cardiovascular system, the nervous system, and in cancer.

Safety and Toxicity

As with any research chemical, PHTPP should be handled with care. It is not intended for use in humans or animals, and its safety and toxicity in these populations is not known.

See Also

• Estrogen receptor
• Selective estrogen receptor modulator
• Estrogen receptor beta