PMEG
PMEG (9-(2-Phosphonylmethoxyethyl)guanine) is a nucleoside analogue and a potent antiviral and antineoplastic agent. It is a member of the class of drugs known as antimetabolites, which work by interfering with the normal metabolic processes within cells.
Chemistry[edit | edit source]
PMEG is a guanine derivative, which means it is structurally similar to one of the four nucleobases used in the synthesis of DNA and RNA. The phosphonylmethoxyethyl group attached to the guanine base is what gives PMEG its unique properties.
Mechanism of Action[edit | edit source]
PMEG works by inhibiting the synthesis of DNA in rapidly dividing cells, such as cancer cells and virus-infected cells. It is incorporated into the growing DNA chain during replication, causing premature termination and leading to cell death.
Clinical Use[edit | edit source]
PMEG has been studied for use in the treatment of a variety of viral infections, including HIV, herpes simplex virus, and cytomegalovirus. It has also been investigated for its potential use in the treatment of certain types of cancer.
Side Effects[edit | edit source]
Like all chemotherapy drugs, PMEG can have serious side effects. These can include nausea, vomiting, diarrhea, and myelosuppression, which is a decrease in the production of blood cells.
Research[edit | edit source]
Research into PMEG is ongoing, with scientists exploring its potential use in new therapeutic areas, as well as ways to minimize its side effects.
See Also[edit | edit source]
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