PNU-282,987

From WikiMD's Wellnesspedia

PNU-282,987 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors. It is used in scientific research to explore the role of this receptor subtype in the release of various neurotransmitters, cognitive function, pain and other conditions.

Pharmacology[edit | edit source]

PNU-282,987 has been shown to increase the release of dopamine in the brain, and increases in acetylcholine release have also been noted. This has led to the suggestion that it may have potential for use in the treatment of conditions such as Alzheimer's disease and schizophrenia, where there is often a reduction in the normal function of the cholinergic system.

Clinical significance[edit | edit source]

While PNU-282,987 has not been developed for use in medicine, it is widely used in scientific research into the function of the α7 nicotinic receptor. This receptor subtype is thought to be involved in a number of neurological conditions, and so drugs that can selectively activate it are valuable tools in this area of research.

See also[edit | edit source]

References[edit | edit source]


PNU-282,987 Resources

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Contributors: Prab R. Tumpati, MD