PODXL2

PODXL2 (Podocalyxin-like 2) is a protein that in humans is encoded by the PODXL2 gene. It is a member of the CD34 family of proteins, which are known to be involved in cell adhesion and cell migration.

Function

PODXL2 is a type 2 transmembrane glycoprotein that is expressed in certain types of stem cells, including hematopoietic stem cells and embryonic stem cells. It is thought to play a role in the development and function of these cells, although the exact mechanisms are not yet fully understood.

Clinical significance

Alterations in the expression of PODXL2 have been associated with a variety of cancer types, including breast cancer, colorectal cancer, and lung cancer. In particular, overexpression of PODXL2 has been linked to poor prognosis in these cancers, suggesting that it may be a potential target for cancer therapy.

Research

Research into the function and clinical significance of PODXL2 is ongoing. Current areas of focus include understanding the role of PODXL2 in cell adhesion and cell migration, as well as its potential as a biomarker for cancer prognosis and treatment response.

See also

• PODXL
• CD34
• Cell adhesion
• Cell migration
• Cancer therapy

References

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