POLE4

POLE4 is a gene that encodes the DNA polymerase epsilon 4, accessory subunit in humans. This gene is part of the larger DNA polymerase family, which is responsible for DNA replication and repair. The POLE4 protein is one of four subunits that make up the DNA polymerase epsilon complex, which plays a critical role in DNA replication and DNA repair.

Function

The POLE4 protein is a small, non-catalytic accessory subunit of the DNA polymerase epsilon complex. This complex is involved in DNA replication and repair, and is essential for the survival of the cell. The POLE4 subunit is thought to enhance the processivity of the DNA polymerase epsilon complex and may also play a role in coordinating the activities of the other subunits.

Clinical Significance

Mutations in the POLE4 gene have been associated with a variety of cancers, including colorectal cancer, endometrial cancer, and ovarian cancer. These mutations can lead to an increased rate of DNA replication errors, which can contribute to the development and progression of cancer.

Research

Research into the POLE4 gene and its associated protein is ongoing. Understanding the function of this gene and its role in DNA replication and repair could lead to new treatments for cancer and other diseases associated with DNA damage.

See Also

• DNA polymerase epsilon complex
• DNA replication
• DNA repair
• Cancer