Peptide YY

Peptide YY (PYY) is a short protein that is part of the peptide family. It is secreted in the gastrointestinal tract and plays a significant role in reducing appetite and food intake, contributing to the regulation of body weight.

Structure

Peptide YY is a 36-amino acid peptide that is a member of the neuropeptide Y family. It is structurally similar to pancreatic polypeptide and neuropeptide Y, all of which share a common amino acid sequence and structure.

Function

Peptide YY is secreted by cells in the ileum and colon in response to feeding. It is released into the bloodstream and travels to the brain, where it acts on the hypothalamus to reduce appetite and food intake. PYY also slows gastric emptying, which prolongs the feeling of fullness after eating.

Clinical significance

Due to its role in regulating appetite and food intake, Peptide YY has been studied as a potential treatment for obesity and eating disorders. Some studies have found that obese individuals have lower levels of PYY in their blood, suggesting that increasing PYY levels could help to reduce overeating and promote weight loss.

Research

Research into the potential therapeutic uses of Peptide YY is ongoing. Some studies have investigated the use of PYY as a weight loss treatment, while others have explored its potential role in treating gastrointestinal disorders such as irritable bowel syndrome and inflammatory bowel disease.

See also

• Neuropeptide Y
• Pancreatic polypeptide
• Obesity
• Eating disorders

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