Aggressive digital papillary adenocarcinoma

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Aggressive digital papillary adenocarcinoma (ADPA) is a rare malignant tumor that primarily affects the digits of the hands and feet. It is characterized by its aggressive behavior and potential for local recurrence and metastasis.

Presentation

ADPA typically presents as a slow-growing, painless mass on the digits. It may be mistaken for a benign lesion such as a cyst or wart. The tumor can occur in individuals of any age but is most commonly diagnosed in adults.

Pathology

Histologically, ADPA is characterized by complex papillary structures and glandular formations. The tumor cells exhibit significant atypia and high mitotic activity. The presence of necrosis and vascular invasion are common features.

Diagnosis

The diagnosis of ADPA is confirmed through a combination of clinical examination, imaging studies, and histopathological analysis. Biopsy and subsequent microscopic examination are essential for definitive diagnosis.

Treatment

The primary treatment for ADPA is surgical excision with wide margins to ensure complete removal of the tumor. Due to the high risk of local recurrence, close follow-up and regular monitoring are necessary. In cases where the tumor has metastasized, additional treatments such as chemotherapy or radiation therapy may be considered.

Prognosis

The prognosis for patients with ADPA varies depending on the stage at diagnosis and the completeness of the surgical excision. Early detection and complete removal of the tumor are critical for a favorable outcome. However, the risk of recurrence and metastasis necessitates long-term follow-up.

See also

• Adenocarcinoma
• Digital tumor
• Papillary carcinoma
• Malignant tumor