Parachloroamphetamine

Parachloroamphetamine (PCA), also known as 4-chloroamphetamine, is a psychoactive drug and research chemical of the phenethylamine and amphetamine chemical classes. It was developed in the early 1960s and has been used in scientific research, but is not known to be used recreationally.

Chemistry

Parachloroamphetamine is a chlorinated derivative of amphetamine. Its full chemical name is 1-(4-chlorophenyl)propan-2-amine. It has a molecular weight of 185.66 g/mol and a chemical formula of C9H12ClN.

Pharmacology

PCA acts as a potent and selective serotonin releasing agent (SRA) with weak effects on dopamine and norepinephrine transporters. This makes it a useful tool in scientific research, particularly in studies involving the serotonin system.

Effects

The effects of PCA in humans are not well studied. However, based on its mechanism of action, it is likely to produce effects similar to other serotonin-releasing agents. These may include euphoria, increased energy, enhanced mood, and increased sociability. However, it may also cause adverse effects such as anxiety, insomnia, and nausea.

Toxicity

PCA is known to be neurotoxic to serotonin neurons. This means that it can cause damage to the brain cells that produce serotonin, potentially leading to long-term mood disorders and cognitive deficits.

Legal status

PCA is not specifically listed in the United Nations' drug control treaties, but it may be considered a controlled substance in some countries under analogue laws.

See also

• Amphetamine
• Phenethylamine
• Serotonin releasing agent