Pentifylline

Pentifylline is a xanthine derivative used as a medication to improve blood flow in patients suffering from peripheral vascular diseases and cerebrovascular insufficiency. It is also known by its brand name, Trental.

Pharmacology

Pentifylline is a phosphodiesterase inhibiting drug which increases red blood cell deformability, reduces blood viscosity and decreases the potential for platelet aggregation and blood clot formation. It works by increasing the amount of oxygen that can be delivered to tissues, improving circulation and reducing pain and other symptoms.

Medical Uses

Pentifylline is primarily used to treat intermittent claudication (pain in the lower legs due to inadequate blood flow). It is also used off-label for the treatment of vascular inflammation, sickle cell disease, and radiation-induced tissue necrosis.

Side Effects

Common side effects of Pentifylline include nausea, vomiting, dizziness, and headache. In rare cases, it can cause serious side effects such as arrhythmia, hypotension, and allergic reactions.

Contraindications

Pentifylline should not be used in patients with recent cerebral and/or retinal hemorrhage or in patients who have previously exhibited intolerance to this product or methylxanthines such as caffeine, theophylline, and theobromine.

Interactions

Pentifylline may interact with anticoagulants, antiplatelet drugs, and blood pressure medications. It is important to inform the healthcare provider of all medications being taken, including over-the-counter drugs and dietary supplements.

See Also

• Xanthine
• Peripheral artery disease
• Cerebrovascular disease
• Phosphodiesterase inhibitor