Pepsinogen c

Pepsinogen C, also known as progastricsin and pepsinogen II, is an enzyme that in humans is encoded by the PGC gene. It is a member of the pepsinogen family and a precursor to the digestive enzyme pepsin.

Function[edit | edit source]

Pepsinogen C is secreted by the gastric chief cells in the stomach. Upon stimulation by gastric acid, it is activated to form pepsin, a proteolytic enzyme that aids in the digestion of proteins. Pepsinogen C is one of several forms of pepsinogen, each of which produces a different form of pepsin upon activation.

Clinical significance[edit | edit source]

Alterations in the PGC gene and pepsinogen C levels have been associated with gastric cancer and atrophic gastritis. Pepsinogen C is often used as a biomarker in the diagnosis and monitoring of these conditions.

References[edit | edit source]

External links[edit | edit source]

PGC at GeneCards

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