Peptide yy
Peptide YY (PYY) is a short protein that is released by cells in the ileum and colon in response to feeding. It is a member of the neuropeptide Y family of proteins.
Function[edit | edit source]
Peptide YY is involved in a variety of biological functions, but it is best known for its role in reducing appetite. After a meal, the amount of PYY in the bloodstream increases, which helps to reduce the feeling of hunger and limit food intake. This effect is thought to be mediated by the Y2 receptor, a protein that PYY binds to in the brain.
In addition to its role in appetite regulation, PYY also has effects on the gastrointestinal tract. It can slow the rate of gastric emptying, which helps to prolong the feeling of fullness after a meal. It also reduces the secretion of digestive enzymes from the pancreas and inhibits the contractions of the gallbladder, which can affect the digestion and absorption of nutrients.
Clinical significance[edit | edit source]
Because of its effects on appetite and digestion, PYY has been studied as a potential treatment for obesity and type 2 diabetes. Some research suggests that people with obesity have lower levels of PYY in their blood, which could contribute to overeating. However, more research is needed to confirm these findings and to determine the safety and effectiveness of PYY-based treatments.
See also[edit | edit source]
References[edit | edit source]
 | This protein-related article is a stub. You can help WikiMD by expanding it. |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
