Phenescaline

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Phenescaline


Phenescaline is a psychedelic drug and phenethylamine derivative which is related to mescaline. It was first synthesized by Alexander Shulgin.

History[edit | edit source]

Phenescaline was first synthesized by Alexander Shulgin. In his book PiHKAL, Shulgin lists the dosage as 120-160 mg and the duration as 10–15 hours. He reports that phenescaline produces an array of psychedelic effects similar to those of mescaline, but with a less intense visual hallucination component.

Chemistry[edit | edit source]

Phenescaline, or 3,5-dimethoxy-4-phenethylphenethylamine, is a phenethylamine with the formula C16H21NO2. It is a member of the 2C family of psychedelic phenethylamines, all of which are derivatives of mescaline.

Pharmacology[edit | edit source]

Like other psychedelic phenethylamines, phenescaline likely acts as a 5-HT2A receptor agonist. The 5-HT2A receptor is responsible for many of the psychedelic effects produced by phenethylamines and other psychedelic drugs.

Effects[edit | edit source]

Phenescaline produces a range of psychedelic effects, including altered states of consciousness, visual hallucinations, and synesthesia. The effects are reported to be less intense than those of mescaline, but longer lasting.

Legal status[edit | edit source]

Phenescaline is not controlled at the federal level in the United States, but it could be considered an analog of a Schedule I drug under the Federal Analogue Act.

See also[edit | edit source]




Contributors: Prab R. Tumpati, MD