Pinazepam

Pinazepam is a benzodiazepine drug that is marketed by the pharmaceutical company Hoffmann–La Roche. It possesses anxiolytic, anticonvulsant, hypnotic, sedative, skeletal muscle relaxant, and amnestic properties. Pinazepam and its metabolite N-desmethyldiazepam are transferred to the developing fetus in utero, but the plasma drug level in the mother is usually significantly higher than in the fetus.

Pharmacology

Pinazepam is a long-acting benzodiazepine drug. It has an active metabolite, N-desmethyldiazepam, which is also a benzodiazepine drug. N-desmethyldiazepam is further metabolized to oxazepam. Pinazepam differs from other benzodiazepines in that it has a propargyl group at the N1 position of the benzodiazepine structure, which increases the drugs' potency.

Medical Uses

Pinazepam is generally prescribed for the short-term treatment of insomnia, anxiety, and the symptomatic relief of acute alcohol withdrawal. It is also used for the management of acute seizures, including those associated with status epilepticus. It may also be used for the treatment of other conditions as determined by a healthcare provider.

Side Effects

Common side effects of pinazepam include drowsiness, light-headedness, unsteadiness, and loss of balance. Less common side effects can include confusion, depression, and changes in behavior. Long-term use of pinazepam can lead to drug tolerance, drug dependence, and withdrawal syndrome upon dose reduction.

Interactions

Pinazepam can interact with a number of other medications, including other benzodiazepines, barbiturates, and alcohol. These interactions can increase the sedative effects of pinazepam and may also increase the risk of respiratory depression.

See Also

• Benzodiazepine
• Hoffmann–La Roche
• Anxiolytic
• Anticonvulsant
• Hypnotic
• Sedative
• Skeletal muscle relaxant
• Amnestic
• N-desmethyldiazepam
• Oxazepam
• Insomnia
• Anxiety
• Status epilepticus
• Drug tolerance
• Drug dependence
• Withdrawal syndrome
• Barbiturates

Pinazepam Resources
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