Pleomorphic fibroma

Pleomorphic fibroma is a benign dermatological condition characterized by the presence of a slow-growing, solitary, and asymptomatic skin nodule. It is a rare type of cutaneous fibroma that typically presents on the skin of adults.

Clinical Presentation

Pleomorphic fibroma typically presents as a solitary, slow-growing, and asymptomatic skin nodule. The size of the nodule can range from a few millimeters to several centimeters. The most common locations for these nodules are the head, neck, and upper extremities. The skin over the nodule is usually normal in appearance, but may occasionally be slightly discolored.

Histopathology

The histopathological examination of a pleomorphic fibroma reveals a well-circumscribed dermal nodule composed of bland spindle cells and scattered pleomorphic multinucleated giant cells. The spindle cells are arranged in a storiform pattern and have a fibroblastic appearance. The multinucleated giant cells have a pleomorphic appearance and contain numerous nuclei. There is usually a variable amount of collagen deposition in the background.

Diagnosis

The diagnosis of pleomorphic fibroma is primarily based on the histopathological examination of the skin nodule. Other diagnostic methods such as immunohistochemistry may be used to confirm the diagnosis and rule out other conditions with similar histopathological features.

Treatment

The treatment of choice for pleomorphic fibroma is surgical excision. The prognosis after surgical excision is excellent, with a low risk of recurrence.

See Also

• Dermatofibroma
• Fibrous histiocytoma
• Skin tumor