Precursor T-cell lymphoblastic leukemia
Precursor T-cell lymphoblastic leukemia (T-ALL) is a type of acute lymphoblastic leukemia that affects T cells. It is characterized by the rapid growth of immature white blood cells known as lymphoblasts. T-ALL is a rare form of cancer, accounting for approximately 15% of all cases of acute lymphoblastic leukemia.
Etiology[edit | edit source]
The exact cause of T-ALL is unknown. However, it is believed to be caused by a combination of genetic and environmental factors. Some studies have suggested that exposure to certain chemicals or radiation may increase the risk of developing T-ALL.
Pathophysiology[edit | edit source]
In T-ALL, the bone marrow produces too many immature lymphocytes, which are a type of white blood cell. These immature cells, known as lymphoblasts, are unable to function properly and can crowd out healthy cells in the bone marrow, leading to a variety of symptoms.
Clinical Presentation[edit | edit source]
Patients with T-ALL often present with symptoms such as fatigue, fever, and unexplained weight loss. Other symptoms may include bone pain, swollen lymph nodes, and frequent infections due to a weakened immune system.
Diagnosis[edit | edit source]
Diagnosis of T-ALL typically involves a complete blood count (CBC), bone marrow biopsy, and cytogenetic analysis. Additional tests may be performed to determine the specific subtype of T-ALL and to guide treatment decisions.
Treatment[edit | edit source]
Treatment for T-ALL typically involves chemotherapy, with the goal of achieving complete remission. In some cases, stem cell transplantation may be considered. The specific treatment plan will depend on a variety of factors, including the patient's age, overall health, and the specific characteristics of the leukemia.
Prognosis[edit | edit source]
The prognosis for T-ALL varies widely and depends on a variety of factors, including the patient's age, overall health, and response to treatment. With modern treatment strategies, many patients with T-ALL are able to achieve long-term remission.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
