Profen (drug class)

Profen is a class of drugs that are commonly used in the treatment of pain, inflammation, and fever. They are part of a larger group of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs), which work by reducing the production of prostaglandins, chemicals that promote inflammation, pain, and fever in the body.

Mechanism of Action

Profens work by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins. There are two types of COX enzymes: COX-1 and COX-2. COX-1 is involved in the production of prostaglandins that protect the stomach lining, while COX-2 produces prostaglandins that cause inflammation and pain. Most profens are non-selective, meaning they inhibit both COX-1 and COX-2. However, some profens are selective for COX-2, which can reduce the risk of gastrointestinal side effects.

Uses

Profens are used to treat a variety of conditions, including:

• Arthritis
• Muscle pain
• Menstrual pain
• Headache
• Fever

They are also used to reduce inflammation and swelling in conditions such as gout and rheumatoid arthritis.

Side Effects

Like all drugs, profens can cause side effects. The most common side effects are related to the gastrointestinal system and can include:

• Stomach pain
• Nausea
• Vomiting
• Diarrhea

In rare cases, profens can cause serious side effects such as ulcers, bleeding, and kidney damage.

Examples of Profens

There are several different types of profens, including:

• Ibuprofen
• Naproxen
• Ketoprofen
• Flurbiprofen

Each of these drugs has its own specific uses, side effects, and contraindications.

See Also

• Non-steroidal anti-inflammatory drug
• Cyclooxygenase
• Prostaglandin