Progressive transformation of germinal centres
| Progressive transformation of germinal centres | |
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| Synonyms | progressive transformation of germinal centers |
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| Field | Infectious disease |
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Progressive transformation of germinal centres (PTGCs) is a reactive lymph node process of undetermined cause.
Signs and symptoms[edit | edit source]
PTGC is usually characterized by localized lymphadenopathy and is otherwise typically asymptomatic.
Diagnosis[edit | edit source]
PTGC is diagnosed by surgical excision of the affected lymph node(s), and examination by a pathologist. The differential diagnosis includes non-neoplastic causes of lymphadenopathy (e.g. cat-scratch fever, Kikuchi disease) and malignancy, i.e. cancer.
Microscopic appearance[edit | edit source]
PTGCs is characterized by:[1]
- follicular hyperplasia (many follicles),
- focally large germinal centres, with poorly demarcated germinal centre (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), and
- an expanded mantle zone.
Treatment[edit | edit source]
PTGC is treated by excisional biopsy and follow-up. It may occasionally recur and in a small proportion of patients has been reported to subsequently develop Hodgkin lymphoma (usually nodular lymphocyte predominant Hodgkin lymphoma).[2][3]
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