Propiophenone

Propiophenone is an organic compound with the chemical formula C₉H₁₀O. It is a ketone that consists of a phenyl group attached to a propionyl group. Propiophenone is a colorless liquid with a sweet odor and is used as an intermediate in the synthesis of various pharmaceuticals and organic compounds.

Structure and Properties

Propiophenone is a simple aromatic ketone with a phenyl group attached to the carbonyl carbon of a propanone. The presence of the phenyl group imparts aromatic characteristics to the compound, influencing its reactivity and physical properties.

Physical Properties

• Molecular Weight: 134.18 g/mol
• Density: 1.008 g/cm³
• Melting Point: 18 °C
• Boiling Point: 218 °C
• Appearance: Colorless liquid
• Odor: Sweet, floral

Chemical Properties

Propiophenone is relatively stable under normal conditions but can undergo typical ketone reactions such as reduction to alcohols, oxidation to carboxylic acids, and condensation reactions.

Synthesis

Propiophenone can be synthesized through the Friedel-Crafts acylation of benzene using propionyl chloride in the presence of a Lewis acid catalyst such as aluminum chloride. This reaction introduces the propionyl group onto the benzene ring, forming propiophenone.

Applications

Propiophenone is used as an intermediate in the synthesis of various pharmaceuticals, including analgesics, antipyretics, and anticonvulsants. It is also used in the production of fragrances and as a flavoring agent due to its sweet aroma.

Safety and Handling

Propiophenone should be handled with care, as it can cause irritation to the skin, eyes, and respiratory tract. Proper personal protective equipment (PPE) such as gloves and goggles should be used when handling the compound.

Also see

• Ketone
• Friedel-Crafts acylation
• Phenyl group
• Pharmaceutical intermediate